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Health Science Campus Artist Showcase to open Feb. 18

The 14th annual Health Science Campus Artist Showcase will take place from Monday, Feb. 18, through Wednesday, April 10, on the fourth floor of Mulford Library.

This year’s exhibit features work from more than 30 artists who are students, faculty and staff in the health sciences from Health Science and Main campuses, as well as UT Medical Center.

On exhibit will be a variety of 2-D and 3-D artwork, including paintings, drawings, photography, sculpture and mixed media.

An artist reception will be held Friday, Feb. 22, from 4 to 6 p.m. on the fourth floor of Mulford Library.

Dr. Paul Brand, UT associate professor emeritus of physiology and pharmacology, will speak at 4:30 p.m. at the reception. His talk is titled “Create Your Own World.”

“I paint and draw first for the simple pleasure of putting color on paper, and then to create paintings that stand out because they fuse realistic images and strong abstract designs,” Brand said.

A longstanding participant in the Health Science Campus Artist Showcase, Brand paints diverse subjects, most often landscapes, but also still-life and abstracts, using watercolors, acrylics, pastels or charcoal. He has four works in this year’s exhibit.

“I love watercolors for their luminous, fresh appearance, acrylics for their immediacy and simplicity, pastels for their intense colors and ease of application, and charcoal for the range of values and richness,” he said.

For the past two decades, paintings by the award-winning artist have been featured at several juried shows. In addition, Brand has taught art classes at the Toledo Botanical Gardens, Toledo Museum of Art and Art Supply Depo.

Like the exhibit, the reception and lecture are free and open to the public. Visitors can view the artwork during regular library hours: Monday through Thursday from 7:30 a.m. to midnight; Friday from 7:30 a.m. to 7 p.m.; Saturday from 9 a.m. to 9 p.m.; and Sunday from 9 a.m. to midnight.

For more information, visit the University Libraries website or contact Jodi Jameson, assistant professor and nursing librarian at Mulford Library, and member of the artist showcase committee, at 419.383.5152 or jodi.jameson@utoledo.edu.

Research integrity officer named

Dr. Debra Boardley, professor in the School of Population Health, has been appointed as the research integrity officer for The University of Toledo.

Boardley has experience in research integrity issues, having served as a member of the University Research Council and as a member of both research misconduct inquiry and investigation committees.

Boardley

She is an expert in food and nutrition behavior, and is particularly concerned about local food issues, including nutrition needs of older adults, children and women.

A registered and licensed dietitian, Boardley holds a master of health science degree from Washington University in St. Louis and a PhD from the University of South Carolina.

Boardley will take over duties from Dr. Wayne Hoss, who came back after retiring from his position as associate dean in the College of Pharmacy and Pharmaceutical Sciences, to serve the University on an interim basis as the research integrity officer. Hoss will still see cases started under his watch through conclusion, with a transition of new cases to Boardley.

“I am pleased that Dr. Boardley is willing to bring her talent and energy to a demanding position at the University that is so important to maintaining our commitment to integrity in research and scholarship,” Dr. Frank Calzonetti, UT vice president for research, said.

Calzonetti thanked Hoss for his service, which included helping to draft a new research misconduct policy.

Doctoral student receives American Heart Association fellowship award

A University of Toledo graduate student has been awarded a highly competitive predoctoral fellowship grant from the American Heart Association.

Hannah Saternos is in her third year of the Pharmacology and Experimental Therapeutics PhD Program in the College of Pharmacy and Pharmaceutical Sciences. The two-year, $53,866 grant, which began Jan. 1, will take her through the completion of her doctoral degree.

Saternos, left, and AbouAlaiwi

Dr. Wissam AbouAlaiwi, associate professor in the Department of Pharmacology and Experimental Therapeutics, said Saternos is an exceptionally bright and dedicated student.

“To bring $54,000 at the predoctoral level is impressive,” AbouAlaiwi said. “Usually students come to the lab, perform their research project, and leave with a decent research experience. For Hannah, it’s more like a major career step. She is a student, she’s taking care of her research — but she’s also training other students, organizing the lab, ordering supplies, and writing grants. She has a very promising future in this field.”

Saternos’ grant application scored in the top 11th percentile, with one reviewer noting she is already “arguably equal to an early to mid-stage postdoctoral fellow in scientific and networking skills.”

The American Heart Association funds 100 to 130 predoctoral fellowships annually.

Originally from the Pittsburgh area, Saternos received both her bachelor’s and master’s degrees from The University of Toledo. She joined AbouAlaiwi’s lab in 2014 and has since published eight research papers.

The primary focus of Saternos’ work is on cilia, hair-like antenna structures that extend from human cells, and the potential role they may play in blood pressure and polycystic kidney disease. She was the first to discover that cilia contain a certain family of receptors and is now investigating whether it might be possible to link and target the receptors as a treatment for those conditions.

AbouAlaiwi said other researchers already have clinically tested drugs that target those receptors elsewhere in the body for treating other disorders.

“If these drugs have proven to be beneficial for polycystic kidney disease or hypertension, you will save a lot of time during the clinical trial periods as you do not have to go through all the safety testing procedure again. Those steps have already been done,” he said. “I think that’s what drew the attention of the American Heart Association to fund this project because it’s a novel idea and it could have an impact on cardiovascular disease in the future.”

There is currently no effective cure or treatment for polycystic kidney disease, a genetic disorder that causes fluid-filled cysts to grow in the kidneys and elsewhere. Ultimately, it can lead to kidney failure.

AbouAlaiwi and Saternos each received grants from the American Heart Association in 2016 to support their work. Read the UT News story about those awards.

Saternos sees her fellowship award as validation that she’s on track for meeting her professional goal of being a research professor in cardiovascular therapeutics.

“I’m naturally curious, and I instantly fell in love with the research project and the lab. Every day I’m excited to be here,” she said. “I’ve always wanted to have my own lab, and getting this award encourages me that dream is realistic. I want to find something I’m passionate about and continue to jump down these rabbit holes. I’m never going to work a day in my life. I genuinely love this.”

Cancer Research Symposium highlights UT’s work in precision therapy

The University of Toledo’s research in immune therapy and precision molecular therapy for treating cancer was acknowledged in 2018 as an area of emerging research excellence with the potential to generate national attention.

At UT’s second Cancer Research Symposium held late last year, Dr. Christopher Cooper, executive vice president for clinical affairs and dean of the College of Medicine and Life Sciences, told assembled faculty and students from across the University they must all work together to turn that potential into reality.

Dr. Christopher Cooper, executive vice president for clinical affairs and dean of the College of Medicine and Life Sciences, delivered the opening remarks for the 2018 UT Cancer Research Symposium. The event, held last month, focused on the work of UT researchers whose findings are advancing precision cancer therapies.

“Our job is to make it an area of excellence,” he said. “We need to move from emerging to being excellent in cancer immune therapy and molecular precision therapy. To get there is going to require success both at the bench and at the bedside.”

The symposium, attended by more than 120 physicians, research scientists and students, was focused on UT’s efforts to create a precision cancer therapy program that will develop more targeted treatments thanks to the huge scientific advances in how we understand not just cancer, but the way it affects specific individuals.

It was only two decades ago that scientists decoded the human genome and just a decade ago that scientists first sequenced one individual’s DNA. At the time, those were extraordinarily lengthy and expensive projects. Today scientists can sequence an individual’s DNA for roughly $1,000, said Dr. F. Charles Brunicardi, director of the Cancer Program in the College of Medicine and Life Sciences.

“We think it will keep decreasing in cost where it will become a routine part of every one of our medical charts,” Brunicardi said. “And that’s where we’re trying to go today with a precision cancer therapy program where we’re using foundation medicine to sequence patient’s cancers and then tailor the therapy toward the targets that we find.”

The symposium featured nearly two dozen UT faculty presenters from the College of Medicine and Life Sciences, College of Pharmacy and Pharmaceutical Sciences, and College of Natural Sciences and Mathematics who discussed topics including genomic sequencing, immunotherapy for breast cancer, novel drug discovery, and how drugs already approved by the U.S. Food and Drug Administration might be able to be repurposed for cancer treatment.

The event also featured a keynote address from Dr. Jian-Ting Zhang who provided perspectives on establishing a targeted drug discovery program. Zhang, formerly professor of pharmacology and toxicology at the Indiana University School of Medicine, will join UT as chair of the Department of Cancer Biology in the College of Medicine and Life Sciences in February.

“This is the best of academia, where we bring together people from different disciplines and different approaches and we tackle important problems that matter to our community, our region and our world,” Cooper said.

More information about the symposium and the presented research can be found by visiting the UT Cancer Research Symposium website.

Submissions sought for 2019 Health Science Campus Artist Showcase

Mulford Library is seeking submissions for its 2019 Health Science Campus Artist Showcase.

The deadline to apply for consideration to be included in the annual event is 5 p.m. Friday, Jan. 11.

The library is accepting submissions from UT faculty, staff and students in the health sciences — nursing, medicine, pharmacy and the health professions — as well as UT Medical Center employees.

To be considered for the show, digital images of artwork can be sent to hscartshow@utoledo.edu, along with a submission form that can be found with guidelines on University Libraries’ website.

Artists will be notified if their submitted pieces have been accepted no later than Wednesday, Jan. 16, and will receive instructions for bringing in their artwork to the library for the showcase.

The showcase will be on display from Feb. 18 through April 10 on the fourth floor of Mulford Library. In the past, artwork included photography, painting, drawing, sculpture, jewelry making, quilting, multimedia, graphics, wood carving and more.

An opening reception featuring a talk by Dr. Paul H. Brand, associate professor emeritus of physiology and pharmacology, and accomplished artist, will be held Friday, Feb. 22, at 4 p.m. in Mulford Library.

Questions about the showcase can be directed to Jodi Jameson, assistant professor and nursing librarian at Mulford Library, who is a member of the artist showcase committee, at 419.383.5152 or jodi.jameson@utoledo.edu.

National science leader and Toledo native to deliver UT commencement address Dec. 15

The head of the nation’s oldest and one of its most prestigious laboratories will return home, as Toledo native Michael Witherell is set to deliver the address during The University of Toledo’s undergraduate commencement ceremony Saturday, Dec. 15.

Witherell, director of the Lawrence Berkeley National Laboratory (Berkeley Lab) in Berkeley, Calif., will address 1,474 candidates for degrees, including 1,437 bachelor’s and 37 associate’s candidates. The event will take place at 11:30 a.m. in Savage Arena on Main Campus.

Witherell

UT’s graduate commencement ceremony is scheduled at 8 a.m. in Savage Arena and will commemorate 641 candidates for doctoral, education specialist and master’s degrees, as well as graduate certificates. Md Kamal Hossain, emerging cancer researcher and candidate for a doctoral degree at the University, will be the speaker.

Both ceremonies are open to the public and can be viewed live on the UT Views website.

Witherell, a distinguished physicist, educator and science leader, developed the foundation for his future at Toledo’s St. Francis de Sales High School. Salutatorian at age 15, he earned a bachelor of science degree from the University of Michigan and a doctorate in experimental physics from the University of Wisconsin in Madison. After a distinguished career as a university professor performing research in particle physics, he devoted himself to leading large research institutions.

In 2016, Witherell was named director of Berkeley Lab, the oldest of the 17 labs in the
U.S. Department of Energy (DOE) national laboratories systems. Berkeley Lab is a global leader in fundamental and applied scientific research in physical, biological, energy, computing and environmental sciences. The lab’s employees have earned 13 Nobel Prizes and played a role in the discovery of 16 elements on the periodic table, among its honors. The lab is managed for the DOE by the University of California.

“Our mission at Berkeley Lab is solving the nation’s most challenging problems through great scientific and technological discoveries. I believe that the national assets in addressing these problems include public universities and the students whom they are educating,” Witherell said.

Before joining Berkeley Lab, Witherell spent six years as director of the Fermi National Accelerator Laboratory in Illinois. He was vice chancellor for research at the University of California in Santa Barbara, where he also held a presidential chair in the Physics Department.

His primary research interest is in studying the nature of dark matter. He was a contributor to the LUX experiment, which in 2016 published the most sensitive search for interactions of dark matter particles with normal matter. He is now part of an international research team that is building a successor to LUX, known as LZ, which will be three orders of magnitude more sensitive. Data collection is expected to start in 2020.

Witherell is a Fellow of the American Physical Society, the American Association for the Advancement of Science, and the American Academy of Arts and Sciences. He chairs the Board of Physics and Astronomy of the National Academies and serves on the National Academies’ Committee on Science, Engineering and Public Policy.

“As a nationally recognized, public research university, The University of Toledo is pleased to have Dr. Witherell as our fall commencement speaker. Research not only helps us to discover new knowledge that advances all areas of study, but also instills critical thinking skills that our students can use to approach problems systematically and come up with solutions that improve everyday life,” UT President Sharon L. Gaber said. “We look forward to Dr. Witherell sharing his insights with our graduates, especially since he grew up in Toledo and has since made tremendous contributions through research.”

Witherell’s personal success can be traced back to the Glass City, as well. He and his wife, Elizabeth Hall Witherell, head of the Princeton Edition of Henry Thoreau’s writings, grew up in the same west Toledo neighborhood and were high school sweethearts. They have a daughter, Lily.

“The foundation for my career and life was my extended family in Toledo,” Witherell said. “Their support and the value they put on education and public service were central to my personal and professional development.”

Hossain

Hossain, the graduate ceremony speaker, is a native of Dhaka, Bangladesh, who came to UT as an industrial pharmacist with a passion to develop innovative medicines.

“I’ve always been interested in studying health-related fields due to the suffering of people in my homeland from different types of disease,” Hossain said. “My focus is to develop a specific targeting approach for a more effective cancer vaccine. My research examined the utilization of a natural antibody already present in human serum that makes the vaccine more convenient to target tumor cells.”

He is a candidate for a doctor of philosophy degree in medicinal chemistry in UT’s College of Pharmacy and Pharmaceutical Sciences.

UT’s fall commencement ceremonies will recognize graduates from the colleges of Arts and Letters; Business and Innovation; Judith Herb College of Education; Engineering; Graduate Studies; Health and Human Services; Natural Sciences and Mathematics; Nursing; Pharmacy and Pharmaceutical Sciences; and University College.

The College of Law will host its commencement ceremony Sunday, May 5, at 1 p.m. in the Thompson Student Union Auditorium. Later that week — Friday, May 10, at
4 p.m. — the College of Medicine and Life Sciences will hold its commencement ceremony in Savage Arena.

For more information, visit the UT commencement website.

UT scientist studies cannabis to control parasites

Anthropologists have observed that the members of a tribe in Africa’s Congo Basin who regularly smoke marijuana have far fewer intestinal parasites than tribe members who don’t use cannabis.

It was a curious finding that suggested an interesting, if unintentional, example of medical marijuana.

Komuniecki

Now a University of Toledo researcher believes he knows why — and potentially how to harness that knowledge to develop new treatments that could rid humans and livestock of roundworms without relying on traditional anthelmintic drugs.

“Studying how nematodes reacted to cannabis gave us a window into a potential new mode of action,” said Dr. Richard Komuniecki, Distinguished University Professor Emeritus of Biological Sciences at The University of Toledo. “Cannabis really limits locomotion in these animals, and they exhibit a dazed and confused behavior. They can’t decide whether to move forward or backward, which is a druggable phenotype.”

Most anti-parasitic drugs currently on the market to treat intestinal parasites work by causing paralysis in the worms, allowing the body to expel them. It is possible the limited locomotion Komuniecki’s work has observed could be enough to release the worm from the host.

While additional animal testing is needed to confirm the theory, the early findings from Komuniecki and his graduate student researchers, Wenjin Law and Mitchell Oakes, are significant because of their potential to add a new treatment in an area that hasn’t seen much recent development.

“In contrast to things like bacteria where we can develop antibiotics, these animals are so closely related to humans that usually compounds that kill nematodes also kill humans,” Komuniecki said. “Anthelmintic drug discovery has been very slow for that reason. Also, resistance is beginning to arise in a lot of the compounds on the market today.”

For his initial research, Komuniecki introduced cannabinoids to a non-parasitic nematode, or roundworm, known as Caenorhabditis elegans. The tiny worms, which have long been used in scientific research, stopped feeding and exhibited erratic motor function once they were exposed to the compounds.

After studying the worm’s reaction, UT researchers determined they could produce the same reaction by targeting the worms’ serotonin receptors. Komuniecki has worked with Dr. Paul Erhardt, Distinguished University Professor and director of UT’s Center for Drug Design and Development, to identify compounds that could be used as treatment.

“The cannabis work allowed us to identify these receptors as novel drug targets,” Komuniecki said.

More than 2 billion people worldwide are affected by parasites, while the global agricultural industry loses billions of dollars a year to parasitic infections.

Komuniecki’s work on parasitic worms has been continuously funded by the National Institutes of Health for more than 35 years.

UT Leadership Institute 2018-19 class announced

Last year, 21 faculty from across the University participated in the second year of the UT Leadership Institute.

The program was launched in fall 2016 by UT President Sharon L. Gaber and Provost Andrew Hsu to provide professional development to help prepare future academic leaders.

“We started this program to help our fantastic faculty members develop into future academic leaders,” Gaber said. “We believe the UT Leadership Institute accelerates success in higher education administration.”

“For faculty who are interested in exploring leadership opportunities in higher education administration, participation in the UT Leadership Institute is an excellent opportunity,” Hsu said. “Our third cohort of faculty represents faculty from eight colleges and University Libraries. I look forward to the many contributions they will make as emerging leaders of the University.”

Following a competitive application process, a third cohort of 22 faculty members was selected to participate in this year’s UT Leadership Institute. This year’s participants are:

• Dr. Ammon Allred, Philosophy, College of Arts and Letters;

• Dr. Jillian Bornak, Physics, College of Natural Sciences and Mathematics;

• Dr. Lucinda Bouillon, School of Exercise and Rehabilitation Services, College of Health and Human Services;

• Dr. Maria Coleman, Chemical Engineering, College of Engineering;

• Dr. Joan Duggan, Medicine, College of Medicine and Life Sciences;

• Dr. Kevin Egan, Economics, College of Arts and Letters;

• Dr. Michael Ellis, Medicine, College of Medicine and Life Sciences;

• Dr. Rodney Gabel, School of Intervention and Wellness, College of Health and Human Services;

• Dr. David Giovannucci, Neurosciences, College of Medicine and Life Sciences;

• Dr. Lynn Hamer, Foundations of Education, Judith Herb College of Education;

• Dr. Dana Hollie, Accounting, College of Business and Innovation;

• Dr. A. Champa Jayasuriya, Orthopedic Surgery, College of Medicine and Life Sciences;

• Dr. David Kennedy, Medicine, College of Medicine and Life Sciences;

• Dr. Lisa Kovach, Foundations of Education, Judith Herb College of Education;

• Sarah Long, School of Exercise and Rehabilitation Sciences, College of Health and Human Services;

• Julia Martin, University Libraries;

• Amy O’Donnell, Management, College of Business and Innovation;

• Dr. Jorge Ortiz, Surgery, College of Medicine and Life Sciences;

• Dr. Youssef Sari, Pharmacology, College of Pharmacy and Pharmaceutical Sciences;

• Dr. Rebecca Schneider, Curriculum and Instruction, Judith Herb College of Education;

• Dr. Qin Shao, Mathematics, College of Natural Sciences and Mathematics; and

• Dr. Puneet Sindhwani, Urology, College of Medicine and Life Sciences.

The first meeting of this year’s UT Leadership Institute cohort was held Oct. 5 and will be followed by monthly meetings throughout the academic year.

Participants will discuss various aspects of leadership in higher education and engage in discussions with members of the UT leadership team and invited speakers, with presentations focusing on leadership styles, critical issues facing administrators, funding, and diversity and inclusion.

President Sharon L. Gaber, second row standing at right, posed for a photo with most of the members of the 2018-19 class of the UT Leadership Institute during last month.

Nov. 27 deadline to order poinsettias from Satellites

Make the season even more festive: Order a poinsettia from the Satellites Auxiliary.

The poinsettias range in price from $6 to $16 and are available in an array of colors, including red, white, pink, and blue with gold. The plants vary in size from 4.5 inches to 7.5 inches and by the number of blooms.

UT students Andrew Yim and Jessica Shippy checked out some poinsettias at the Satellites Auxiliary’s sale last year in Rocket Hall.

Fresh wreathes measuring 14 inches also are available for $11.

“Every year we do this sale as more of a service for our campuses than as a fundraiser,” Lynn Brand, president of the Satellites, said. “We keep our costs very low, and the small amount of profits benefit our scholarships for the College of Medicine and Life Sciences, the College of Nursing, and the College of Pharmacy and Pharmaceutical Sciences.”

Poinsettia order forms must be received by Tuesday, Nov. 27. Email lynn.brand@utoledo.edu, fax to 419.383.3206, or drop off to Volunteer Services in Dowling Hall Room 75.

Orders will be available for pickup from 10 a.m. to 2 p.m. on Main Campus Monday, Dec. 3, in the Rocket Hall Lobby and on Health Science Campus Tuesday, Dec. 4, in the Four Seasons Bistro Atrium. All poinsettias will be foiled and sleeved.

Payment is due at the time of pickup; options include cash, checks, and payroll deduction on Health Science Campus.

The Satellites Auxiliary is a group designed to promote education, research and service programs; provide support of patient programs in accordance with the needs and approval of administration; conduct fundraising events; and offer volunteer services.

For more information on the annual sale, contact Brand at lynn.brand@utoledo.edu.

UT research discovers link between refined dietary fiber, gut bacteria and liver cancer

Many of the processed foods we find on grocery store shelves have been loaded up with highly refined soluble fibers such as inulin, a popular probiotic that recently received approval from the Food and Drug Administration to be marketed as health-promoting.

But a new study from The University of Toledo’s College of Medicine and Life Sciences is raising serious questions about whether the risks of adding refined fiber to processed foods may significantly outweigh the benefits.

Dr. Vishal Singh, center, a Crohn’s and Colitis Foundation Fellow at the University, recently authored a study published in the journal Cell that found a link between highly refined soluble fibers and liver cancer. He is pictured with fellow researchers Beng San Yeoh, left, a PhD student, and Dr. Matam Vijay-Kumar, director of the UT Microbiome Consortium and associate professor of physiology and pharmacology.

Dr. Matam Vijay-Kumar, director of the UT Microbiome Consortium and associate professor in the UT Department of Physiology and Pharmacology, and his research team recently investigated if a diet enriched with refined inulin might help combat obesity-associated complications in mice.

While the inulin-containing diet did stave off obesity in 40 percent of mice, many of those same mice went on to develop liver cancer at the end of the six-month study.

“The findings shook us,” Vijay-Kumar said, “but at the same time we recognized their potential importance and accepted the challenge of exploring how processed dietary soluble fiber was inducing liver cancer.”

Although this study was performed in mice, it has potential implications for human health. It also suggests, researchers say, that enriching processed foods with refined, fermentable fiber should be approached with great caution.

“We fully appreciate that the fibers present in whole foods like fruits and vegetables are healthy,” Vijay-Kumar said. “Because of that, fortifying or adding purified fiber to processed food sounds logical. However, our results suggest it may in fact be dangerous.”

The findings were published in the Oct. 18 issue of Cell, one of the world’s leading biological journals.

There are two basic types of naturally occurring dietary fiber, soluble and insoluble. Soluble fibers are fermented by gut bacteria into short-chain fatty acids. Insoluble fibers pass through the digestive system unchanged.

While both types are beneficial, the concern raised in the study relates to how gut bacteria break down the highly refined fiber that is added to some processed foods as a dietary supplement.

Dr. Vishal Singh, a Crohn’s and Colitis Foundation Fellow at The University of Toledo and lead author of the paper, said refined fiber is a new addition to our diets and we are in the very early stages of understanding the risks and benefits it may present.

“Soluble fibers added to processed foods are not part of a natural meal,” Singh said. “The inulin used in this study is from chicory root, which is not a food we would normally eat. In addition, during the extraction and processing of the fiber, it goes through a chemical process. We don’t know how the body responds to these processed fibers.”

Chicory root is used as a source of inulin to fortify fiber in processed foods.

The mice that developed liver cancer in this study had altered and elevated gut bacteria, a condition known as dysbiosis. Intriguingly, the researchers observed no evidence of liver cancer in inulin-fed mice that were treated with broad-spectrum antibiotics to deplete gut bacteria.

The UT team collaborated with researchers at Georgia State University who performed a similar study in germ-free mice that completely lack gut bacteria. The absence of liver cancer in those mice further confirmed the contributory role of gut bacteria.

The bacteria collectively known as gut microbiota degrade and digest soluble fibers via fermentation. To inhibit that fermentation process, the UT researchers fed mice beta acids derived from Humulus lupulus — a plant more commonly known for producing the hops that go into beer to prevent spoilage from fermentation.

“Strikingly, feeding beta-acids to inulin-fed mice averted liver cancer, which further reinforce our hypothesis that gut bacterial dysmetabolism primarily driving liver cancer in these mice,” Singh said.

Researchers also found they could halt the development of liver cancer by intervening to replace inulin with the insoluble fiber cellulose.

“Cellulose could not be fermented by gut bacteria present in mice or humans. This finding again highlights the link between bacterial fermentation of soluble fiber and liver cancer development in these mice,” said Beng San Yeoh, a graduate student in Vijay-Kumar’s lab and another lead author of this study.

Researchers said their findings suggest the need for more studies that look at human consumption of the type of refined fiber found in processed foods.

“Our study is going against the conventional wisdom of what people think, that fiber is good, no matter how they get it,” Vijay-Kumar said. “We do not want to promote that fiber is bad. Rather, we highlight that fortifying processed foods with refined soluble fiber may not be safe or advisable to certain individuals with gut bacterial overgrowth or dysbiosis, whose abnormal fermentation of this fiber could increase the susceptibly to liver cancer.”

The study was supported by the National Cancer Institute of the National Institute of Health.